In a randomized clinical trial of 58 adults scheduled for major elective surgery, personalized prehabilitation that included twice-weekly tailored remote coaching across physical, nutritional, cognitive, and mindfulness domains led to pronounced reductions in proinflammatory immune signaling, greater improvements in physical and cognitive performance, and significantly fewer severe postoperative complications compared with a standard prehabilitation program delivered via written guidance, suggesting that individualized preoperative conditioning may enhance immune readiness and clinical recovery before major surgery.

Source: JAMA Surgery