- Study identified modifiable risk factors for sudden cardiac arrest.
- Interventions targeting lifestyle, physical, psychosocial, socioeconomic, and environmental factors could reduce SCA risk.
- Forced expiratory volume in 1 second was the single largest risk factor.
- 63% of SCA cases could be prevented through elimination of unfavorable and intermediate profiles.
- Study employed hypothesis-free, data-driven EWAS framework followed by MR validation.
- Limitations include potential limited generalizability due to study population composition.
Source: Canadian Journal of Cardiology
