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Conexiant chevron_right Cardiology chevron_right How Immune Cells Sabotage the Heart in Duchenne Muscular Dystrophy
From the Journals

How Immune Cells Sabotage the Heart in Duchenne Muscular Dystrophy

New research highlights macrophages’ role in disrupting the heart's nerve communication, offering potential targets for therapy.

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In Duchenne muscular dystrophy (DMD), researchers discovered that macrophages release chondroitin sulfate proteoglycan-4 (CSPG4), disrupting the neuro-cardiac junction and contributing to heart dysfunction. The study identified potential therapy targets, including givinostat, which reduced CSPG4 levels and restored normal neuro-cardiac signaling in mouse models, offering insights for conditions involving cardiac fibrosis and inflammation.

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