Clinical Report: GCS May Expand CTRCD Assessment
Overview
A retrospective study indicates that global circumferential strain (GCS) shows moderate correlation with global longitudinal strain (GLS) in identifying mild cancer therapy-related cardiac dysfunction (CTRCD).
Background
Cancer therapy-related cardiac dysfunction (CTRCD) is a significant concern for patients undergoing cancer treatment, as it can lead to adverse cardiovascular outcomes. Accurate assessment of cardiac function is crucial for timely intervention and management. The study explores the potential of GCS as an alternative to GLS, particularly in cases where GLS assessment is hindered by suboptimal imaging conditions.
Data Highlights
| Measure | CTRCD Group | No CTRCD Group |
|---|---|---|
| Mean Baseline LVEF | 56% | 58% |
| Mean GLS | −19% | −19% |
| Mean GCS | −21% | −21% |
| Mean Relative Change in GCS | −19% | −5% |
| Mean Relative Change in GLS | −19% | −4% |
Key Findings
- GCS and GLS showed moderate correlations in both CTRCD and non-CTRCD groups.
- 92% concordance in relative reductions of GCS and GLS among patients with CTRCD.
- 93% concordance in relative reductions of GCS and GLS among patients without CTRCD.
- No significant differences in baseline LVEF, GLS, or GCS between groups.
- GCS may be more feasible in patients with challenging acoustic windows.
Clinical Implications
Further prospective studies are needed to establish the clinical utility of GCS and validate cutoff values for routine use.
Conclusion
The study highlights the potential role of GCS in the assessment of CTRCD.
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