The PARAMEDIC-3 trial compared intraosseous and intravenous drug administration strategies during out-of-hospital cardiac arrest. There was no significant difference in 30-day survival rates between the two approaches. Researchers—who involved over 6,000 patients across 11 emergency medical systems in the United Kingdom in the trial—concluded that the vascular access route used did not significantly impact survival outcomes in patients experiencing an out-of-hospital cardiac arrest. Further research may be needed to explore alternative strategies for improving survival and neurological outcomes in this population.