- Higher levels of apolipoprotein B-containing particles and lipoprotein(a) linked to greater risk of coronary artery disease.
- Total apoB-P count, rather than lipoprotein type or size, most accurately reflected lipid-related risk.
- Measurement of apoB-P and Lp(a) may offer the most accurate lipid-related risk assessment.
- Adding apoB-P to clinical risk models improved 10-year prediction accuracy.
- Lp(a) levels independently increased CAD risk.
- The findings were confirmed in an independent cohort of participants from the Swedish SIMPLER study.
- Study recommends consideration of both apoB-P and Lp(a) concentrations for adequate assessment of atherogenic risk from dyslipidemia.
Source: European Heart Journal
