- Trial enrolled 160 adult patients with early-stage squamous cell carcinoma of the anus, most female with tumors ≤ 4 cm.
- Patients were randomly assigned to receive standard radiation dose of 50.4 Gy or a lower dose of 41.4 Gy with concurrent mitomycin and capecitabine.
- 92% of patients in the reduced-dose group achieved complete response at 6 months compared with 87% from standard dose.
- The lower dose group experienced fewer side effects and better treatment compliance.
- Symptoms improved by 6 weeks and returned to baseline by 6 months.
Source: The Lancet Oncology
