A clinical protocol detailed in BMJ Open Respiratory Research aims to reduce unplanned hospital admissions for patients with chronic obstructive pulmonary disease and severe asthma, particularly those with multiple comorbidities. The initiative, running from January 2024 to December 2025, emphasizes the role of indoor air quality in triggering acute events and incorporates predictive modeling and digital health support for proactive care. The protocol is based on four key strategies: management change, personalized interventions, advanced digital support, and comprehensive assessment.