- Long COVID occurred in 12.4% of the cohort, rising to 66.7% after severe infection.
- Women showed higher long COVID rates (15.1% vs 8.5%) and more trajectory associations.
- Researchers reconstructed 15 years of diagnoses across 106 chronic conditions.
- 23 conditions and 23 two-condition trajectories were linked to long COVID; 34 trajectories for women.
- Nearly 45.6% of trajectories involved mental health–neurologic patterns (depression, anxiety, migraine, stress).
- Temporality was key: 73.7% of trajectories increased risk only in a specific sequence.
- No significant genetic correlations were found, though some polygenic scores were associated in women.
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