A recent study revealed significant differences in airway fungal composition between pulmonary hypertension (PH) patients and healthy individuals. The analysis showed increased levels of Purpureocillium, Issatchenkia, and Cyberlindnera in PH patients, while Peroneutypa, Simplicillium, and Metarhizium were notably reduced. These differences remained consistent across PH classifications and disease severities. Correlation analysis found associations between Ascomycota abundance and pulmonary vascular resistance, mPAP, and cardiac output. The study provides evidence for the potential causal relationship between altered lung/airway mycobiomes and PH development, highlighting the need for future research on microbiome signatures in PH.

Source: BMC Medicine