- Study in BMC Medicine identified significant differences in airway fungal composition in pulmonary hypertension patients.
- Increased levels of Purpureocillium, Issatchenkia, and Cyberlindnera were found in PH patients.
- Notably reduced are Peroneutypa, Simplicillium, and Metarhizium.
- Correlation analysis showed associations between Ascomycota abundance and pulmonary vascular resistance, mPAP, and cardiac output.
- The study provides evidence for the potential causal relationship between altered lung/airway mycobiomes and PH development, emphasizing the need for further microbiome research in PH.
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