1. Neotame, a potent artificial sweetener, was found in the majority of disposable e-cigarettes sold in the US in 2024.
2. Neotame concentrations in vaping products were higher compared with the reference food product, mint candy.
3. Its safety profile for inhalation exposure remains unclear.
4. Synthetic cooling agents, such as WS-23 and menthol, were frequently present in the devices.
5. Further research is needed to evaluate neotame's potential respiratory and systemic effects.

Source: JAMA