Superagers aged 80 years and older demonstrate a unique neurobiological profile associated with successful aging: preserved memory and distinct brain anatomy, including thicker cortical regions and lower tau pathology.
"The panel urges clinicians to consider the pretest probability of AD pathology for each patient when deciding whether or not to use a BBM test,” and not as a standalone diagnostic tool.
Combination use of antihypertensive, lipid-lowering, and antidiabetic agents shows associations with cognitive preservation and postmortem neuropathologic changes in aging cohorts.
Patients from the MeninGene study contributed serum samples over 5 years, revealing that autoimmune processes rarely drive long-term cognitive problems after bacterial meningitis.
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A new study identified human pegivirus in the brains and blood of patients with Parkinson’s disease, revealing virus-linked immune and gene expression changes that varied by genetic background.
A study of patients who underwent epilepsy surgery in the language-dominant temporal lobe identified key risk factors for early naming decline and found that the degree of early decline predicts long-term recovery.