Pathology
Partner With Us
Advertisement
Conexiant chevron_right Pathology chevron_right RNA Testing Uncovers Hidden Gene Fusions in AML
Conference News Association for Molecular Pathology (AMP) Annual Meeting

RNA Testing Uncovers Hidden Gene Fusions in AML

Michigan team finds cryptic leukemia-defining rearrangements missed by standard cytogenetics.

Conexiant
article Full Article subject Summary summarize Notecard
  1. RNA-based fusion testing found hidden AML-defining rearrangements missed by standard cytogenetics.
  2. Among 601 AML cases, 14.8% had gene fusions detected by the enhanced panel.
  3. Twenty-three fusions (≈4% of AML) were cytogenetically cryptic.
  4. Cryptic findings included NUP98 (12 cases) and KMT2A (6 cases) rearrangements.
  5. Additional undetected fusions included PML::RARA, CBFB::MYH11, DEK::NUP214, KAT6A::CREBBP, and NPM1::MLF1.
  6. RNA testing resolved uncertain or unavailable cytogenetic results in five more cases.
  7. Researchers recommended routine inclusion of RNA-based fusion detection in AML workups.

Daily News

Stay up to date with the latest clinical headlines and other information tailored to your specialty.