An autopsy study conducted in Japan evaluated men with sporadic transthyretin cardiac amyloidosis, revealing that amyloid deposits in the prostate correlate significantly with cardiac involvement severity. In 35 cases, 51% showed amyloid using hematoxylin-eosin (H&E), with 83% confirmed by Congo red staining. Notably, patients with H&E-detectable deposits displayed higher cardiac amyloid scores and a higher mortality rate from cardiac amyloidosis. Common comorbidities included hypertension and diabetes. This research emphasizes the prostate's value in detecting amyloidosis when cardiac symptoms are not apparent.

Source: Pathology