1. Somatic and germline mutations in DNA polymerase linked to cancer.
2. 31 pathogenic missense variants identified.
3. Poled and Pold1 variants lead to hypermutated tumors.
4. Endometrial cancer most prevalent among proofreading-deficient tumors.
5. Median diagnosis ages vary: 42 for colorectal, 50 for endometrial.
6. Variant-specific risks noted for early-onset cancers.
7. Limitations in sample quality and data completeness acknowledged.
8. All colorectal cancers in the study were adenocarcinomas.

Source: Modern Pathology