A recent study highlights that obtaining five or more biopsy specimens from mild-to-moderate ulcerative lesions, particularly in the terminal ileum, results in granuloma detection rates exceeding 70% in Crohn’s disease patients. Analyzed data from 308 patients revealed that larger specimen sizes and higher quantities significantly increase detection rates. Mild-to-moderate lesions yielded more granulomas compared to severe ones. The research underscores the importance of specimen strategy in enhancing diagnostic efficacy for Crohn’s disease.

Source: Pathology – Research and Practice