July 15, 2025

Genetic Markers Don’t Guide RA Drug Choice

A large UK study found no significant difference in treatment effectiveness between abatacept and adalimumab for rheumatoid arthritis, regardless of patients’ HLA-DRB1 genetic profiles.

Conexiant

July 15, 2025

Cementless Knee Implants Show Superior Outcomes in Patients With Obesity

A new review comparing knee implant methods in obese patients finds cementless fixation may improve implant survival and reduce loosening compared with cemented approaches, especially in patients with BMI ≥35 kg/m².

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July 15, 2025

Methotrexate Shows No Knee OA Symptom Benefit, Study Finds

A 52-week randomized clinical trial found no significant difference between methotrexate and placebo in reducing pain or effusion-synovitis in patients with inflammatory knee osteoarthritis.

Conexiant

June 30, 2025

Can Typos Change a Diagnosis?

Large language models used in clinical decision-making may offer different treatment recommendations depending on how a patient writes their message—even when the medical facts remain unchanged.

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June 24, 2025

Do CBC Ratios Predict RA Mortality?

Elevated SIRI, NLR, and MLR from routine blood counts independently predicted higher all-cause mortality among patients with rheumatoid arthritis.

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April 21, 2025

Lupus Clusters Show Distinct Disease Patterns

Cluster 2 patients exhibited ‘a more severe form of the disease, marked with frequent serositis and haematological manifestations, renal and neurological involvement,’ and had poorer outcomes over time.

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June 12, 2025

Gene Variants Linked to CPPD Risk

A large genetic study in U.S. veterans has identified ENPP1 and RNF144B as genes associated with calcium pyrophosphate deposition disease, suggesting potential for targeted treatment approaches.

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April 30, 2025

New AI Sensor Diagnoses Osteoarthritis and Rheumatoid Arthritis

A new AI-assisted gold sensor distinguished osteoarthritis from rheumatoid arthritis with 98.1% accuracy by analyzing synovial fluid, offering a fast, noninvasive diagnostic option, researchers report.

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April 18, 2025

Gout Remission Linked to Lower Urate, Fewer Flares

Remission in gout after urate-lowering therapy was seldom after 1 but high after 5 years, finds a five-year NOR-Gout study tracking 211 patients.

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