Researchers investigated the complex role of lipoproteins, especially high-density lipoproteins (HDL), in the pathogenesis of age-related macular degeneration (AMD). Utilizing data from the National Institutes of Health’s All of Us Research Program, they identified a U-shaped association between HDL levels and AMD risk. Both low and high HDL levels were significantly associated with increased AMD risk, and genetic components, such as ABCA1, LIPC, and LPA, were found to have implications in AMD progression. They also highlighted potential applications of genetic data from the All of Us program in future studies and subgroup analyses. 

Source: Ophthalmology