August 25, 2025

Discontinuation and Resumption of Larotrectinib in Pediatric Patients With TRK Fusion Sarcomas and Related Mesenchymal Tumors

As reported in the Journal of Clinical Oncology by Mascarenhas et al, follow-up of a cohort of pediatric patients with TRK fusion sarcomas and related mesenchymal tumors treated with larotrectinib sho...

The ASCO Post

August 25, 2025

Botensilimab Plus Balstilimab in Relapsed or Refractory Metastatic Sarcomas

In a phase Ib study reported in the Journal of Clinical Oncology, Wilky et al found that the combination of botensilimab (Fc-enhanced anti–CTLA-4 antibody) and balstilimab (anti–PD-1 antibody) yielded...

The ASCO Post

August 25, 2025

High-Risk Rhabdomyosarcoma: Long-Term Outcomes With Maintenance Chemotherapy

Long-term follow-up of the European Paediatric Soft Tissue Sarcoma Study Group RMS2005 trial was recently reported.

The ASCO Post

August 22, 2025

Dendrimer-Based SN38 Nanoparticle Shows Favorable Safety and Activity in Advanced Solid Tumors

In an early-phase study reported in the Journal of Clinical Oncology, Liu et al evaluated the efficacy and safety of DEP-SN38, a polylysine-based dendrimer-nanoparticle conjugate of SN38, the active m...

The ASCO Post

August 22, 2025

Older Women With High-Risk Breast Cancer: Addition of Adjuvant Chemotherapy to Hormone Therapy

In a French-Belgian phase III trial (ASTER 70s) reported in The Lancet, Brain et al examined the survival benefit of adding adjuvant chemotherapy to hormone therapy in women aged ≥ 70 years with estro...

The ASCO Post

August 22, 2025

Breast Cancer Surveillance in Pre– vs Post–COVID-19 Periods

In a study reported as a research letter in JAMA Oncology, Hahn et al found that the proportion of U.S. patients with breast cancer undergoing annual surveillance imaging was lower in the post– vs pre...

The ASCO Post

August 22, 2025

EBRT With Focal Boost in Localized Prostate Cancer: 10-Year Follow-up

As reported in the Journal of Clinical Oncology by Guricová et al, 10-year outcomes of the Dutch-Belgian phase III FLAME trial showed continued benefit of a focal radiotherapy boost to the intraprosta...

The ASCO Post

August 22, 2025

Survival in Older Patients With Cancer and Diabetes: GLP-1 RAs vs Other Glucose-Lowering Drugs

Glucagon-like peptide-1 (GLP-1) receptor agonists were found to be associated with lower all-cause mortality than dipeptidyl peptidase-4 (DPP-4) inhibitors, with no significant difference from sodium-...

The ASCO Post

August 22, 2025

Real-World Study Highlights Gaps in Hypomethylating Agent Treatment for MDS

Researchers have identified age-, sex-, and race-related disparities around treatment with hypomethylating agents for patients with myelodysplastic syndromes in the United States. The receipt of hypom...

The ASCO Post