1. Multinational cohort study on smoking cessation pharmacotherapies in early pregnancy
2. No evidence of increased risk of major congenital malformations associated with NRT, varenicline, or bupropion during early pregnancy
3. Over 5.2 million births between 2001 and 2020 in Australia (New South Wales), New Zealand, Norway, and Sweden were analyzed
4. No significant increase in the prevalence of major congenital malformations in the exposed groups compared to unexposed group
5. Sensitivity analyses supported the primary results, indicating no increased risk
6. Larger studies may be needed to further assess rare outcomes and exposures to bupropion

Source: JAMA Internal Medicine