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Conexiant chevron_right ObGyn chevron_right Early TMPSMX Use Linked to Birth Defects
From the Journals

Early TMP-SMX Use Linked to Birth Defects

TMP-SMX is prescribed earlier in gestation than β-lactams, placing fetal exposure closer to the window of organogenesis, which may contribute to elevated malformation risk observed in first-trimester use.

Conexiant
Full Article Summary Notecard
  1. Study of 71,604 pregnancies.
  2. Compared risks of TMP-SMX vs β-lactams.
  3. Found increased risk of congenital malformations with TMP-SMX.
  4. Significant relative risk for severe cardiac malformations and cleft lip/palate.
  5. Used data from Merative MarketScan Database (2006-2022).
  6. Suggested careful antibiotic prescribing in early pregnancy.
  7. Limitations included administrative data reliance.
  8. Results emphasize alternative antibiotics during early gestation.

Source: JAMA Network Open

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