- Case-control study across 8 U.S. healthcare systems found no association between COVID-19 vaccination in early pregnancy and miscarriage risk.
- 888 pregnant patients analyzed, with similar vaccination exposure rates in spontaneous abortion and live birth groups.
- Adjusted odds ratios showed no increased risk with vaccine exposure.
- Manual review of medical records confirmed pregnancy outcomes and minimized outcome misclassification.
- Standardized protocols validated live births, supporting the conclusion that COVID-19 vaccination during early pregnancy is not associated with an increased risk of miscarriage.
Source: Obstetrics & Gynecology
