"These data highlight the role of subjective patient-related parameters in the response to cytokine inhibition and suggest that a high-volume representation of the disease in the CNS—involving more frontal-associative brain circuits—increases the likelihood to respond to TNF inhibitor.
Cognitive functional therapy demonstrates durable effects on disability and pain intensity at 3 years, with outcomes remaining stable beyond the 12-month mark in patients with chronic low back pain
Researchers found bedtime sublingual cyclobenzaprine reduced pain versus placebo and improved sleep, fatigue, and function with mostly mild oral adverse events.
Conexiant
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Presymptomatic treatment with risdiplam was associated with improved motor development and survival without permanent ventilation in infants with spinal muscular atrophy (SMA), according to 24-month results from the phase 2 RAINBOWFISH trial published in the New England Journal of Medicine.
Older adults with low B-vitamin status and elevated homocysteine may have increased odds of cognitive dysfunction, and carriers of the ApoE e4 genotype faced compounded risk.
“This study builds on the emerging literature suggesting behavioral therapy may have utility as an initial therapy for the most common urinary symptoms affecting persons with PD."