Researchers demonstrate first successful targeted removal of extra chromosome 21 in Down syndrome cells using CRISPR-Cas9, achieving up to 30.6% effectiveness in laboratory studies.
Data from the phase III ReNeu trial showed the kinase inhibitor led to an overall response rate of 41% in adult patients and 52% in pediatric patients.
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Doses greater than 75 mg/d of antipsychotics significantly increased the risk of tardive dyskinesia, with odds ratios up to 3.5, according to a claims database study of corporate healthcare beneficiaries.
New research examining 1003 young adults shows persistent reductions in working memory-related brain activation among heavy cannabis users, independent of recent use or substance dependence diagnosis.