A recent population-based cohort study from the Rotterdam Study demonstrated that long-term use of nonsteroidal anti-inflammatory drugs (NSAIDs), particularly those without known effects on amyloid-β, is associated with a 12% reduction in dementia risk. Short-term and intermediate-term use, on the other hand, showed a slight increased risk. These findings show the potential for dementia prevention through prolonged NSAID exposure, particularly in the absence of the APOE-ε4 allele, though the researchers stressed that they do not justify recommending long-term NSAID treatment due to known adverse effects, particularly in older adults. Because the results conflict with previous findings from randomized controlled trials, further research is needed.

Source: Journal of the American Geriatrics Society