1. New guidelines recommend a tiered treatment strategy for cUTIs.
2. Initial antibiotic choice depends on sepsis status.
3. Preferred agents include cephalosporins and fluoroquinolones.
4. Early transition to oral therapy is advised for improving patients.
5. Emphasis on de-escalating therapy based on culture results.
6. Guidelines are conditional and based on low to moderate evidence.
7. Specific recommendations for patients with unique risk factors.
8. Focus on antimicrobial stewardship to improve outcomes.

Source: IDSA