1. EBV seropositivity significantly associated with higher mortality in pediatric sepsis.
2. 15% mortality in EBV-seropositive vs 3% in seronegative.
3. Hyperferritinemia and macrophage activation syndrome linked to EBV.
4. Study involved 320 patients aged infant to 18 years.
5. Limitations include temporal ambiguity and lack of control group.
6. Highlight the need for further research on EBV and immune disorders.

Source: JAMA Network Open