1. Single intramuscular dose of benzathine penicillin G is effective for early syphilis.
2. 76% serologic response at 6 months in one-dose group.
3. No clinical relapses observed during follow-up. 
4. 249 patients enrolled, 199 evaluable for primary outcome.
5. Injection-site pain reported by 76% in one-dose group.
6. Benefits include reduced treatment frequency and costs.
7. Study conducted across 10 US sites.
8. Findings support principles of antimicrobial stewardship.

Source: The New England Journal of Medicine