Fetal hematopoietic stem cells in Down syndrome are 'primed' for differentiation, as revealed by single-cell multi-omics of over 1.1 million cells, potentially explaining early hematological abnormalities.
In a phase 3 trial, 67% of children treated with omalizumab tolerated 600 mg of peanut protein, a dramatic increase over just 7% with placebo, highlighting omalizumab’s potential in managing pediatric food allergies.
A recent study found that topical vitamin D was associated with a reduction in proinflammatory cytokine levels and the severity of inflammatory acne lesions. Additional studies are needed to gain a clearer understanding of its mechanism of action.
New research compares human milk antibody levels against infectious pathogens across different income countries, revealing important insights for infant health.
A recent study has found a unique subset of macrophages in the synovial tissue of patients with rheumatoid arthritis, showing early signs before clinical onset, which could have implications for early diagnosis and treatment response.
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Two phase III clinical trials reveal promising results of once-daily roflumilast cream, 0.15%, in improving symptoms of atopic dermatitis within 4 weeks.
Eighty FCCs had properties that warrant further investigation for potential health concerns, such as carcinogenic, mutagenic, and reproductive toxicity.