- Cholesterol metabolism may play a role in psoriasis pathogenesis
Increased cholesterol synthesis and oxysterol signaling may promote inflammation via RORγ and IL-17 pathways. - UVB phototherapy may act through metabolic as well as immune pathways
In addition to known effects, UVB may reduce cholesterol production and alter downstream signaling. - Photoproducts of UVB exposure may have anti-inflammatory effects
Vitamin D, lumisterol, and tachysterol derivatives can inhibit RORγ activity and reduce IL-17 signaling, with additional effects via VDR and other receptors. - Novel vitamin D metabolites are potential therapeutic candidates
CYP11A1-derived compounds (e.g., 20(OH)D3) may offer noncalcemic options, though clinical validation is needed. - Evidence remains preliminary and mechanistic
Key aspects—including the role of lumisterol/tachysterol derivatives and cholesterol synthesis pathways in human skin—require further study.
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