A comprehensive review in the Journal of Investigative Dermatology examines the relationship between SARS-CoV-2 infections and skin manifestations, highlighting acute and long-term dermatologic impacts linked to immune system responses. The study reveals a wide range of cutaneous manifestations, from common rashes to severe lesions, associated with distinct immunologic pathways. It emphasizes the prevalence, clinical characteristics, and immunopathogenic mechanisms of skin conditions during COVID-19 infections and post-COVID conditions and underscores the importance of recognizing and managing these manifestations for improved patient outcomes.