Hair graying results from a complex interplay of biological, genetic, and environmental factors. Melanin production by melanocytes is essential for hair pigmentation, but oxidative stress, genetic variations, psychological stress, hormonal imbalances, nutritional deficiencies, certain medications, and environmental exposures all contribute to the onset and progression of gray hair. Various treatments, including antioxidant supplementation, stress management, nutritional correction, hormonal therapies, and experimental approaches, are being investigated to target the underlying biological causes of graying.

Source: Clinical, Cosmetic and Investigational Dermatology