1. Intraepidermal Langerhans cell collections are specifically associated with allergic contact dermatitis.
2. The study involved 170 skin biopsies from patients evaluated with patch testing and clinical correlation.
3. Heavy dermal eosinophilic infiltration was found to be more common in non-allergic cases.
4. Presence of Langerhans cell collections was associated with an increased likelihood of allergic contact dermatitis.
5. Median age of the cohort was 63 years; 68% were female.
6. The presence of eosinophils alone is not specific to ACD.
7. Langerhans cell collections may aid in distinguishing ACD from other etiologies.

Source: Journal of the American Academy of Dermatology