1. HSV-1 alters the human genome by reorganizing host DNA during infection.
2. The virus hijacks the cell’s transcription machinery and redirects transcriptional resources.
3. Chromatin undergoes widespread condensation, and RNAP II becomes concentrated in viral replication compartments.
4. The overall 3D spatial organization of chromatin is resilient to major physical reshaping induced by HSV-1.
5. HSV-1's genome preferentially contacts gene-rich regions, particularly in transcriptionally active compartments. 
6. The study provides insight into potential antiviral strategies targeting HSV-1's manipulation of the host genome.
7. Research may inform the development of therapeutic approaches leveraging the identified targets for antiviral intervention.

Source: nature communications