- Ethinylestradiol and norethindrone show a more than 200-fold increased reporting rate of melasma.
- Majority of melasma cases occurred in female patients aged 18 to 35 years.
- Investigators noted the strong association between hormonal therapies, especially combined oral contraceptives, and melasma.
- Clinicians are advised to monitor for drug-induced pigmentation disorders and counsel patients accordingly.
Source: BMC Pharmacology and Toxicology
