1. Pilot study differentiates between topical steroid withdrawal (TSW) and atopic dermatitis (AD).
2. Patients with TSW had persistent symptoms after discontinuing topical corticosteroid use.
3. Multiomics analysis revealed increased NAD⁺ oxidation and mitochondrial complex I overexpression in TSW patients.
4. Open-label treatment with complex I inhibitors showed subjective symptom improvement.
5. Proposed preliminary diagnostic criteria for TSW based on symptom prevalence.
6. Emphasized the need for further investigation into TSW.

Source: Journal of Investigative Dermatology