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Conexiant chevron_right Dermatology chevron_right Beta HPV Driven Cutaneous SCC Resolved After TCR Signaling Correction
FDA & Government News From the Journals

Beta-HPV–Driven SCC Resolved After TCR Signaling Correction

Case study shows cutaneous squamous cell carcinoma linked to beta-human papillomavirus cleared following T-cell immune restoration.

Conexiant
Full Article Summary Notecard
  1. Beta-HPV can directly cause SCC in immunocompromised patients.
  2. Significant case study involved 34-year-old with ZAP70 mutations.
  3. Hematopoietic cell transplantation restored T-cell function.
  4. Complete resolution of SCC and HPV lesions post-treatment.
  5. Case challenges previous beliefs about beta-HPV's role in SCC maintenance.

Sources: The New England Journal of Medicine, National Institutes of Health

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