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Conexiant chevron_right Dermatology chevron_right Benzene Formation in Benzoyl Peroxide Formulations Role in
From the Journals

Benzene Formation in Benzoyl Peroxide: Formulation’s Role

Researchers found that benzene formation in benzoyl peroxide products is influenced by formulation factors, with hot processing increasing levels and antioxidants reducing them.

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  1. Benzene levels in benzoyl peroxide products may range from 0.19 to 35.3 parts per million.
  2. Excipient selection and temperature control during manufacturing have a significant impact on benzene formation.
  3. Leave-on formulations were associated with lower benzene concentrations compared with wash-off products.
  4. No statistically significant association was observed between benzoyl peroxide concentration and benzene levels.
  5. Further prospective studies are recommended to confirm these findings and ensure the safety of over-the-counter benzoyl peroxide products.

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