1. Trial compared lactated Ringer's solution and normal saline.
2. Conducted in 7 hospitals with 43,626 patients.
3. 90-day mortality: 7% (lactated Ringer's) vs. 8% (saline).
4. No significant differences in readmissions or other outcomes.
5. COVID-19 limited the ability to detect small differences.
6. Study aligns with meta-analyses suggesting slight mortality benefits for balanced crystalloids.

Source: The New England Journal of Medicine