- Specific plasma metabolites, such as alpha-ketobutyrate and 1-palmitoyl-2-linoleoyl-GPI, were found to be significantly protective against late-life atherosclerotic cardiovascular disease events.
- The study emphasized the potential clinical significance of these metabolites and highlighted the role of genetic regulation in metabolite levels.
- The research was funded by the Pennsylvania Department of Health and the National Institutes of Health, with no disclosed individual conflicts of interest.
- The findings offered new insights into the relationship between mid-life metabolic profiles and long-term cardiovascular health.
- Researchers stressed the need for further investigation to establish causality and evaluate the therapeutic potential of these metabolites in ASCVD prevention and management.
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