- BedMed study: Followed 3,357 adults with hypertension over 4.6 years.
- Dosing comparison: No significant difference in cardiovascular events between morning and bedtime dosing.
- Nighttime blood pressure: Lower in the bedtime group, but no translation to clinical improvement.
- Adherence: 95% morning group vs. 83% bedtime group at 6 months.
- Consistent findings with the TIME trial, no benefit from bedtime dosing.
Source: JAMA Network
