1. Awake prone positioning (APP) for at least 10 hours/day is associated with higher survival without intubation in COVID-19 patients with acute hypoxemic respiratory failure.
2. A meta-analysis of 14 randomized clinical trials comprising 3,019 participants demonstrated the benefits of APP compared to supine positioning.
3. Prolonged duration of APP confers greater benefits.
4. Lead study author: Jian Luo of the Respiratory Medicine Unit and Oxford National Institute for Health and Care Research Biomedical Research Centre at NDM Experimental Medicine at the University of Oxford.
5. Subgroup analyses revealed more pronounced effects of APP in specific patient groups based on age, body mass index, timing of implementation, and clinical parameters.

Source: JAMA Internal Medicine