A network meta-analysis assessed the impact of different face masking protocols during intravitreal injection procedures, comparing outcomes of masking policies—universal masking, physician-only masking, or no-talking protocols—on post-intravitreal injection endophthalmitis rates. The study found that no-talking policies reduced endophthalmitis incidence, and physician masking was more effective than universal masking. However, the researchers raised concerns regarding communication issues and safety with no-talking policies. They also highlighted the need to optimize other modifiable risk factors, such as antisepsis protocol and use of pre-filled syringes.