- Routine platelet measurements during pregnancy may help identify women who do not respond to low-dose aspirin and develop preeclampsia.
- Researchers analyzed data from 993 women enrolled in an ancillary study of the FORECAST trial.
- Platelet count, mean platelet volume, and the PC/MPV ratio were measured at gestational stages.
- Platelet indices were associated with aspirin nonresponsiveness when combined with maternal factors.
- Opal immunofluorescence staining revealed increased platelet activation in women with preeclampsia.
- RNA sequencing showed altered genes related to platelet activity and vascular remodeling between preeclamptic and nonpreeclamptic women.
Source: BMC Medicine
