An editorial in the Journal of Intensive Medicine highlighted sex-related disparities in antibiotic dosing for sepsis that may influence both treatment efficacy and toxicity. Women experience up to 30% more adverse drug reactions due to physiological differences affecting drug metabolism, including higher body fat and fluctuating hormone levels. Current renal function equations underestimate glomerular filtration in women, leading to dosing inaccuracies. Meanwhile, men’s augmented renal clearance may cause underdosing. Women were also less likely to receive early broad-spectrum antibiotics. Researchers called for sex-specific pharmacologic modeling and therapeutic drug monitoring to improve individualized dosing and sepsis outcomes.